BEMÆRK: Ansøgningsfristen er overskredet
Do you want to be part of a team that is discovering new fundamental biological mechanisms involved in development of metabolic and immunological diseases?
An excellent opportunity is available to join Ubiquitin Signalling and Inflammation Lab at the Department of Biotechnology and Biomedicine, Technical University of Denmark (DTU), for a fully funded 3-year PhD Scholarship.
About the position
We are seeking a creative and highly motivated PhD student with a background in molecular cell biology or similar. The successful candidate will work under the supervision of Associate Professor Rune Busk Damgaard to investigate how ubiquitination regulates metabolic signalling and how cells respond and adapt to metabolic and inflammatory stresses.
The student will use molecular biology , biochemical assays , and advanced imaging techniques in mammalian cell culture and disease model systems to identify novel ubiquitin-dependent and disease-associated signalling mechanisms in cellular metabolism.
The Ubiquitin Signalling and Inflammation Lab uses a combination of molecular cell biology , biochemistry , and quantitative proteomics to unravel the fundamental biological processes that control crosstalk and integration between inflammatory and metabolic signalling pathways. Our aim is to identify druggable signalling mechanisms that will advance therapy for patients suffering from inflammatory diseases, metabolic disorders, and cancer.
In the past years, our lab has gained deep insights into how the Met1-linked ubiquitin-specific E3 ubiquitin ligase LUBAC and its counteracting deubiquitinase OTULIN regulate immunologic and metabolic homeostasis and how dysregulation of LUBAC and OTULIN leads to development of autoinflammation, dysmetabolism, and cancer (Damgaard et al., Cell 2016; Damgaard et al., EMBO Mol Med 2019; Damgaard et al., Cell Death Differ 2020; Jahan et al., Cell Death Differ 2021). We are now expanding these efforts.
The PhD student will spearhead an ambitious project aiming to identify new mechanisms by which LUBAC and OTULIN regulate the cellular response to metabolic stresses. Such mechanisms may be druggable and may be involved in the development of metabolic and inflammatory diseases as well as cancer.
Relevant reading:
Damgaard et al., Cell (2016): https://pubmed.ncbi.nlm.nih.gov/27523608/
Damgaard et al., Cell Death Differ (2020): https://pubmed.ncbi.nlm.nih.gov/30804083/
Jahan et al., Cell Death Differ (2021): https://pubmed.ncbi.nlm.nih.gov/33441937/
Qualifications and assessment criteria
The successful candidate must hold an M.Sc. degree
(or equivalent) in a relevant discipline, e.g. biomedicine, biochemistry, molecular biology, biotechnology, or immunology, and be ambitious, curious,
and highly motivated
. The candidate is expected to have a strong interest in fundamental scientific discoveries and their translational potential.
Essential skills and competences:
- Broad background knowledge in cell biology and biochemistry
- Practical laboratory experience in cell and/or molecular biology
In addition, we are looking for a candidate with any of these desirable - but not essential - skills and competences:
- Research experience within the fields of metabolic signalling, autophagy, lysosome or mitochondrial biology, or the ubiquitin system
- Hands-on experience with mammalian cell culture and cell transfection
- Hands-on experience with biological imaging techniques, e.g. confocal fluorescence microscopy
- Hands-on experience with immunoblotting (Western blot)
- Hands-on experience with immuno-/affinity precipitation of protein complexes or proximity labelling methods such as bioID or APEX
- Hands-on experience with molecular biology techniques, including PCR, molecular cloning, and mutagenesis
- Experience with quantitative (image) data analysis and statistics, e.g. using R Studio, Prism, or other relevant software
- Organisational skills and the ability to work in a team as well as independently
- Excellent communication skills in written and spoken English
- Experience with CRISPR/Cas9-mediated gene editing
Desired personal qualities:
- Willingness to learn new skills and methods
- Being self-motivated and proactive
- The ambition and persistence to succeed within a competitive research field
You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.
About us
The successful candidate will join a vibrant, ambitious, and international research team
. The Ubiquitin Signalling and Inflammation Lab
offers a collaborative, supportive, and dynamic work environment focusing on excellence in research and mentoring. Read more about the lab and our research here: http://bioengineering.dtu.dk/usi
The Ubiquitin Signalling and Inflammation Lab is embedded in the Department of Biotechnology and Biomedicine, Technical University of Denmark. The department is highly interdisciplinary and a leading department within life sciences in Denmark, covering both fundamental, technological, and applied aspects of biomedical research. The Department offers access to a large suite of state-of-the-art core facilities, including proteomics, bioimaging, biophysics, and structural biology.
Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education
.
Assessment
The assessment of the applicants will be made by Associate Professor Rune Busk Damgaard together with relevant project partners.
We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.
You can read more about career paths at DTU here .
Starting date
Starting date is 1 January 2024 (or as agreed upon by all parties). The position is a full-time position.
Further information
Informal enquiries and requests for further information should be directed to Associate Professor Rune Busk Damgaard (rudam@dtu.dk
)
If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU.
Application procedure
Your complete online application must be submitted no later than 10 September 2023 (23:59 Danish time).
Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please ckick "Apply now", fill out the online application form, and attach all your materials in English in one PDF file . The file must include:
- A cover letter describing your motivation, ambition, and how your technical skills are suited for the project
- Detailed curriculum vitae (CV)
- List of publications (if any)
- Names and contact details (including email address and phone number) for two academic references
- Master’s (M.Sc.) and Bachelor’s (B.Sc.) degree diplomas as well as grade transcripts (in English) including official description of grading scale
You may apply prior to obtaining your master's degree but cannot begin before having received it.
Applications received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
The Department of Biotechnology and Biomedicine (DTU Bioengineering) addresses challenges of societal and scientific importance within biotechnology, biomedicine, food technology and human health. The department is based on both basic and applied research and employs tools from biochemistry, biophysics, chemistry, cellular biology, immunology, microbial ecology and physiology, bioinformatics and bio-engineering. The department has extensive collaboration with national and international research units and industries. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff.
Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Lyngby-Taarbæk Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
Danmarks Tekniske Universitet, Anker Engelunds Vej, 2800 Kongens Lyngby
-Ansøgning:
Ansøgningsfrist: 10-09-2023; - ansøgningsfristen er overskredet
Ved skriftlig henvendelse: https://efzu.fa.em2.oraclecloud.com/hcmUI/CandidateExperience/da/sites/CX_1/job/2183
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5901452
