BEMÆRK: Ansøgningsfristen er overskredet
General information
The research group of Prof. Alexander K. Buell at the department of Biotechnology and Biomedicine at the Technical University of Denmark (DTU Bioengineering) is looking to recruit a PhD student, to start from 1st of April 2024 or as soon as possible afterwards. Our research group is situated within the section of Protein Chemistry and Enzyme Technology (PCET), where world-leading expertise in protein chemistry and structural biology is concentrated. Our laboratory performs cutting-edge experimental research in the field of protein and peptide self-assembly and aggregation. The applied methods include protein engineering as well as various spectroscopy, scattering, biosensing and microfluidics techniques and we work on a range of protein systems the aggregation of which is associated with human disease. The overall aim of our research is to achieve a profound mechanistic understanding of protein and peptide assembly into ordered (e.g. fibrillar) and disordered (amorphous, liquid droplet) condensed phases and of the physico-chemical factors and sequence determinants that drive it. To achieve these goals, we also collaborate with structural, computational and medical biologists. The motivation behind our research is to enable rational control of such assembly processes in the context of human disorders, nutrition, protein biotechnology as well as in the creation of novel types of functional biomaterials.
Research project
In this project, which is funded by a prestigious ERC consolidator grant (EMMA), the aim is to generate a much better understanding than is currently available of the link between the amino acid sequence of an intrinsically disordered protein (IDP) and its condensation and aggregation properties. We will develop a range of novel high throughput methods to explore the sequence dependence of the assembly into condensates and fibrils of alpha-synuclein (related to Parkinson’s disease) and TDP-43 (related to amyotrophic lateral sklerosis). We also collaborate with world-leading computational and bioinformatic groups in order to extract the maximal possible insight from the data we generate. More detailed information on the project can be obtained at the interview stage.
The successful candidate will contribute to the establishment and application of a new experimental methodology with the aim of probing the relationship between protein sequence and assembly into condensates and aggregates at high throughput. Further tasks will include:
- Assistance in and involvement with other research projects and topics in the group
- Help with the supervision of BSc and MSc students
- Taking responsibility for the functioning of research equipment
- Experimental design, data analysis, writing of scientific articles and presentations at conferences and meetings
Qualifications
Candidates must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree in experimental Biology, Biochemistry, Biophysics, Biotechnology or related fields.
The successful candidate should
- Have excellent English communication skills.
- Have some practical laboratory experience with recombinant protein production and biophysical characterisation in the context of an MSc thesis
- Be interested in the quantitative study of biomolecular systems in vitro
- Feel comfortable in an interdisciplinary research environment of openness and collaboration
Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education
.
We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.
Starting date is 1.5.2024 or as soon as possible thereafter. The period of employment is 3 years.
You can read more about career paths at DTU here http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths.
Further information
May be obtained from Prof. Alexander K. Buell, tel.: +45 4525 4061, email: alebu@dtu.dk
or can be found on the group’s website, https://buelllab.org
More information about the SEEDFOOD project can be found here: https://food.ku.dk/english/research_at_food/research-projects/2022/seedfood-functional-and-palatable-plant-seed-storage-proteins-for-sustainable-foods/
You can read more about the department at https://www.bioengineering.dtu.dk/
If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU.
Application procedure
Your complete online application must be submitted no later than 31 January 2024 (23:59 Danish time).
Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file . The file must include:
- A letter motivating the application (cover letter, stating explicitly why the candidate applies for this position and why she/he is particularly suited for this position)
- Curriculum vitae
- Grade transcripts and BSc/MSc diploma (in English) including official description of grading scale
- List of publications, if any
- Contact details of 1-2 academic contacts who are prepared to provide a professional reference for the candidate.
You may apply prior to obtaining your master's degree but cannot begin before having received it.
Applications received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Lyngby-Taarbæk Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
Danmarks Tekniske Universitet, Anker Engelunds Vej, 2800 Kongens Lyngby
-Ansøgning:
Ansøgningsfrist: 31-01-2024; - ansøgningsfristen er overskredet
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5971782
