BEMÆRK: Ansøgningsfristen er overskredet
We have two open PhD positions affiliated to the Center for Microbial Secondary Metabolites (CeMiSt - https://cemist.dtu.dk/ ), which is a Center of Excellence funded by the Danish National Research Foundation. The research area for both positions falls within microbial natural product chemistry with a focus on analysis of the interaction between secondary metabolite-producing microorganisms. We are looking for two ambitious younger chemists with documented experience in microbial natural product chemistry and an interest in chemical ecology. In both positions you will have the unique opportunity to work with cutting edge analytical instrumentation in the investigation into the natural roles of natural products.
PhD position #1 ( in-situ detection). This PhD project will be focusing on the detection of microbial secondary metabolites from marine and soil environments with the ambition to understand how they affect microbial diversity and functionality in both natural (in situ detection) and engineered systems. Your main analytical approach will be based on the development of new sampling techniques for trapping and detecting trace amounts of microbial metabolites. You will acquire data for metabolomics analysis using state-of-the-art high-resolution mass spectrometry instrumentation including LC-MS, MALDI imaging and NMR spectroscopy, working closely with the DTU Metabolomics Core, and the DTU NMR Center.
PhD position #2 (biotransformations). This PhD project will focus on elucidating the chemical fate (e.g. biotransformations) of secondary metabolite(s) in microbial communities and evaluate the phenomenon from a chemical perspective. The project will focus on specific natural product classes and how metabolites from different microbial sources are sensed and treated by microbiota. The project will mainly involve aspects of natural products chemistry and big data handling, with a strong emphasis on microbial extractions and mass spectrometry (LC-MS/MS and MALDI-ToF MS). Furthermore, MALDI Imaging will be used to map biotransformations spatially within the metabolome.
Responsibilities and qualifications
- Targeted/untargeted analysis aiming at detection of trace amounts of known secondary metabolites in natural niches (e.g. algal or soil samples) using extract based approaches or direct MS detection (Mass Spectrometry Imaging)
- Isolation and structural elucidation of unknown secondary metabolites from both natural niches and lab cultures
- Comparative metabolomics of multi-species microbial model systems
- Compound identification using software and databases, such as MSDial, MZmine, AntiBase and web-based MS/MS databases
- Experimental design and multivariate analyses using in-depth knowledge of MALDI and LCMS based metabolomics
You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.
Applicable for all scholarships
Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education
.
Assessment
To qualify for this position you should have several of the following qualifications
- A strong background in analytical chemistry or natural product chemistry
- Highly motivated by the structural complexity of microbial natural products and their roles in nature
- Previous hands-on experience with LC-MS, MALDI-imaging and NMR is advantageous
- Previous experience in different chromatography methods to characterize microbial secondary metabolites is advantageous
- Experience in large metabolomics data handling, with knowledge of R and/or Python programming languages is advantageous
- Strong writing and communication skills
- You are hard-working and dedicated to your work
- You are a team player with a desire to work closely and help your colleagues to succeed
- Excellent communication skills in English
We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and appointment terms
The appointment for both PhD positions will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.
You can read more about career paths at DTU here http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths.
Further information
You can read more about the Department at www.bioengineering.dtu.dk
You can contact associate professor Ling Ding (lidi@dtu.dk ), professor Thomas Ostenfeld Larsen (tol@bio.dtu.dk ), Aaron John Christian Andersen (ajca@dtu.dk ) or center leader Lone Gram (gram@bio.dtu.dk ) for details about the position.
If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU.
Application
Your complete online application must be submitted no later than 21 November 2023 (23:59 Danish time).
Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file .
The file must include:
- A letter motivating the application (cover letter)
- Curriculum vitae
- Grade transcripts and BSc/MSc diploma (in English) including official description of grading scale
- Information from at least two references
Please indicate which project you are applying for (title from the above list of PhD projects or individual research projects).
Incomplete applications will not be considered. You may apply prior to obtaining your master's degree but cannot begin before having received it.
Applications received after the deadline will not be considered.
All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.
The Center for Microbial Secondary Metabolites is a Center of Excellence funded by the Danish National Research Foundation. The Center started 1st of January 2018 and got an extension recently. The Center is based at the Technical University of Denmark and hosted by Department of Biotechnology and Biomedicine (DTU Bioengineering), and is led by Professor Lone Gram. Three DTU departments and 10 senior faculty participate in the Center, and 15 PhD students and postdocs are currently hired by CeMiSt.
The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science- and biotech industries and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.
Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Lyngby-Taarbæk Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
Danmarks Tekniske Universitet, Anker Engelunds Vej, 2800 Kongens Lyngby
-Ansøgning:
Ansøgningsfrist: 21-11-2023; - ansøgningsfristen er overskredet
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5931102
